BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_RMGI_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_RMGI_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANOS1 anosmin 1
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C3 complement component 3
CADM1 cell adhesion molecule 1
CAST calpastatin
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELL2 elongation factor, RNA polymerase II, 2
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GPC3 glypican 3
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KHNYN KH and NYN domain containing
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MCL1 myeloid cell leukemia 1
MORC4 MORC family CW-type zinc finger 4
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PDLIM5 PDZ and LIM domain 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RRAD Ras-related associated with diabetes
SELE selectin E
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D1 TSC22 domain family, member 1
UBQLN2 ubiquilin 2
WLS wntless Wnt ligand secretion mediator
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACSL5 acyl-CoA synthetase long-chain family member 5
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CBX6 chromobox homolog 6
CCND2 cyclin D2
CD58 CD58 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL4A1 collagen, type IV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
EFHD2 EF-hand domain family, member D2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FBXO11 F-box protein 11
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGFR3 fibroblast growth factor receptor 3
HBD hemoglobin, delta
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGHM immunoglobulin heavy constant mu
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LAMA3 laminin, alpha 3
LBR lamin B receptor
MAT2A methionine adenosyltransferase II, alpha
MMD monocyte to macrophage differentiation-associated
NPTX2 neuronal pentraxin II
PGBD5 piggyBac transposable element derived 5
PLAGL1 pleiomorphic adenoma gene-like 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB13 RAB13, member RAS oncogene family
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF167 ring finger protein 167
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SLC30A1 solute carrier family 30 (zinc transporter), member 1
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM45A transmembrane protein 45A
TNS3 tensin 3
TRIB2 tribbles pseudokinase 2
VCAN versican
VIM vimentin
ZBTB18 zinc finger and BTB domain containing 18
ZMYND8 zinc finger, MYND-type containing 8