BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_RKO_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_RKO_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL15A1 collagen, type XV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DSG2 desmoglein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
EXPH5 exophilin 5
F11R F11 receptor
FAM129A family with sequence similarity 129, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXL12 F-box and leucine-rich repeat protein 12
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
FST follistatin
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA4 heat shock 70kDa protein 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IPO13 importin 13
IVNS1ABP influenza virus NS1A binding protein
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
MAGEA12 melanoma antigen family A12
MAGEA4 melanoma antigen family A4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MPO myeloperoxidase
MSMB microseminoprotein, beta-
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO1D myosin ID
ORC1 origin recognition complex, subunit 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PKP2 plakophilin 2
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM30B transmembrane protein 30B
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ANKRD10 ankyrin repeat domain 10
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
BTN3A1 butyrophilin, subfamily 3, member A1
C1S complement component 1, s subcomponent
CCND1 cyclin D1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EXOSC4 exosome component 4
FKBP11 FK506 binding protein 11, 19 kDa
GAK cyclin G associated kinase
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
HLTF helicase-like transcription factor
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER2 immediate early response 2
IFITM2 interferon induced transmembrane protein 2
ITGB5 integrin, beta 5
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
KRT10 keratin 10, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LPCAT1 lysophosphatidylcholine acyltransferase 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MFSD10 major facilitator superfamily domain containing 10
MTCL1 microtubule crosslinking factor 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
PAN2 PAN2 poly(A) specific ribonuclease subunit
PI3 peptidase inhibitor 3, skin-derived
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PLSCR3 phospholipid scramblase 3
PRR5 proline rich 5 (renal)
RAE1 ribonucleic acid export 1
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
RPS21 ribosomal protein S21
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SFN stratifin
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SRPRB signal recognition particle receptor, B subunit
TACC3 transforming, acidic coiled-coil containing protein 3
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TSPO translocator protein (18kDa)
UBE2S ubiquitin-conjugating enzyme E2S
Funding