BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_PC3_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_PC3_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CCNL1 cyclin L1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNPY3 canopy FGF signaling regulator 3
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DFNA5 deafness, autosomal dominant 5
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FAM49A family with sequence similarity 49, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GREB1 growth regulation by estrogen in breast cancer 1
GTPBP2 GTP binding protein 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGL immunoglobulin lambda locus
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF11 Kruppel-like factor 11
KLF6 Kruppel-like factor 6
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR2 lysophosphatidic acid receptor 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MFSD10 major facilitator superfamily domain containing 10
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEB nebulin
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
ORC1 origin recognition complex, subunit 1
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS4 regulator of G-protein signaling 4
RIPK2 receptor-interacting serine-threonine kinase 2
RPL10 ribosomal protein L10
RRAD Ras-related associated with diabetes
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STAR steroidogenic acute regulatory protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ASPH aspartate beta-hydroxylase
B3GNT1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CALU calumenin
CCNA2 cyclin A2
CCND1 cyclin D1
CD99 CD99 molecule
CDC123 cell division cycle 123
CDC14B cell division cycle 14B
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CP ceruloplasmin (ferroxidase)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYZ crystallin, zeta (quinone reductase)
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAIM Fas apoptotic inhibitory molecule
FAM69A family with sequence similarity 69, member A
FBXO3 F-box protein 3
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
HOXA10 homeobox A10
HOXC10 homeobox C10
IFITM2 interferon induced transmembrane protein 2
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
LASP1 LIM and SH3 protein 1
LIPA lipase A, lysosomal acid, cholesterol esterase
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
PBK PDZ binding kinase
PDHX pyruvate dehydrogenase complex, component X
PGM1 phosphoglucomutase 1
PIP prolactin-induced protein
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
PRRC2B proline-rich coiled-coil 2B
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PURA purine-rich element binding protein A
PXMP2 peroxisomal membrane protein 2, 22kDa
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP5 receptor accessory protein 5
RPA1 replication protein A1, 70kDa
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORD sorbitol dehydrogenase
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TMCO3 transmembrane and coiled-coil domains 3
TNC tenascin C
TUBB tubulin, beta class I
TYRP1 tyrosinase-related protein 1
UBE3C ubiquitin protein ligase E3C
WSB2 WD repeat and SOCS box containing 2