BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_OV7_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_OV7_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CARS cysteinyl-tRNA synthetase
CCP110 centriolar coiled coil protein 110kDa
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EPS8L2 EPS8-like 2
EVI2A ecotropic viral integration site 2A
FAM134B family with sequence similarity 134, member B
FGFR3 fibroblast growth factor receptor 3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITM2A integral membrane protein 2A
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LDHB lactate dehydrogenase B
LITAF lipopolysaccharide-induced TNF factor
MACROD1 MACRO domain containing 1
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MZB1 marginal zone B and B1 cell-specific protein
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RAD9A RAD9 homolog A (S. pombe)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RFC2 replication factor C (activator 1) 2, 40kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
UGDH UDP-glucose 6-dehydrogenase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPO7 exportin 7
YARS tyrosyl-tRNA synthetase
ZMYM2 zinc finger, MYM-type 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
APMAP adipocyte plasma membrane associated protein
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CD99 CD99 molecule
CDC20 cell division cycle 20
CEP55 centrosomal protein 55kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNN1 calponin 1, basic, smooth muscle
CNN3 calponin 3, acidic
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM3C family with sequence similarity 3, member C
FAM69A family with sequence similarity 69, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GSTT1 glutathione S-transferase theta 1
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LOC100505650 uncharacterized LOC100505650
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
METTL3 methyltransferase like 3
MMP10 matrix metallopeptidase 10
MUC16 mucin 16, cell surface associated
NCAM1 neural cell adhesion molecule 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NTS neurotensin
PAM peptidylglycine alpha-amidating monooxygenase
PCDH7 protocadherin 7
PDGFC platelet derived growth factor C
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PON2 paraoxonase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSRP1 arginine/serine-rich protein 1
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
STEAP1 six transmembrane epithelial antigen of the prostate 1
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TUBB4B tubulin, beta 4B class IVb
TXNRD1 thioredoxin reductase 1
Funding