BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH596_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH596_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CLDN3 claudin 3
CPE carboxypeptidase E
CREB3L2 cAMP responsive element binding protein 3-like 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FGL2 fibrinogen-like 2
FHL2 four and a half LIM domains 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGB1 golgin B1
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
HOXB6 homeobox B6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MX1 MX dynamin-like GTPase 1
MYO1D myosin ID
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCL1 phospholipase C-like 1
PMM2 phosphomannomutase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RAP1GAP2 RAP1 GTPase activating protein 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SQLE squalene epoxidase
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPD52 tumor protein D52
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331
ZNF395 zinc finger protein 395
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANOS1 anosmin 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CALD1 caldesmon 1
CAST calpastatin
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNG1 cyclin G1
CHRDL1 chordin-like 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CXCL5 chemokine (C-X-C motif) ligand 5
DCK deoxycytidine kinase
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DUSP22 dual specificity phosphatase 22
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
HAT1 histone acetyltransferase 1
HMGN3 high mobility group nucleosomal binding domain 3
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KLC1 kinesin light chain 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LUM lumican
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MGST2 microsomal glutathione S-transferase 2
MRPS30 mitochondrial ribosomal protein S30
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP210 nucleoporin 210kDa
NUP62 nucleoporin 62kDa
PBX1 pre-B-cell leukemia homeobox 1
PCGF2 polycomb group ring finger 2
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPID peptidylprolyl isomerase D
PRDX6 peroxiredoxin 6
PROM1 prominin 1
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RAB4A RAB4A, member RAS oncogene family
RBBP4 retinoblastoma binding protein 4
RBM14 RNA binding motif protein 14
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOBTB3 Rho-related BTB domain containing 3
RPA1 replication protein A1, 70kDa
SAMM50 SAMM50 sorting and assembly machinery component
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORD sorbitol dehydrogenase
SPTBN1 spectrin, beta, non-erythrocytic 1
STOM stomatin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TMPO thymopoietin
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSPAN8 tetraspanin 8
UNG uracil-DNA glycosylase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
XPO1 exportin 1