BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH508_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH508_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AEBP1 AE binding protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC11A C-type lectin domain family 11, member A
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EZR ezrin
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FST follistatin
GUSBP11 glucuronidase, beta pseudogene 11
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
JUN jun proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LUM lumican
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD10 major facilitator superfamily domain containing 10
MGP matrix Gla protein
MMP11 matrix metallopeptidase 11
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYRF myelin regulatory factor
NCAM1 neural cell adhesion molecule 1
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDLIM3 PDZ and LIM domain 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLVAP plasmalemma vesicle associated protein
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PRTN3 proteinase 3
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RAB2A RAB2A, member RAS oncogene family
RHOB ras homolog family member B
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPARCL1 SPARC-like 1 (hevin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQRDL sulfide quinone reductase-like (yeast)
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TXNIP thioredoxin interacting protein
VIM vimentin
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADI1 acireductone dioxygenase 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CALML4 calmodulin-like 4
CCDC47 coiled-coil domain containing 47
CCND3 cyclin D3
CDK4 cyclin-dependent kinase 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHPT1 choline phosphotransferase 1
CLN5 ceroid-lipofuscinosis, neuronal 5
COX11 COX11 cytochrome c oxidase copper chaperone
CRYAB crystallin, alpha B
CSK c-src tyrosine kinase
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EBNA1BP2 EBNA1 binding protein 2
F12 coagulation factor XII (Hageman factor)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GRWD1 glutamate-rich WD repeat containing 1
GTF3A general transcription factor IIIA
GTPBP8 GTP-binding protein 8 (putative)
HAT1 histone acetyltransferase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXA10 homeobox A10
HOXD1 homeobox D1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM2 interferon induced transmembrane protein 2
KIAA0226L KIAA0226-like
KIF2C kinesin family member 2C
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC16A leucine rich repeat containing 16A
LRRC8D leucine rich repeat containing 8 family, member D
LTF lactotransferrin
LY75 lymphocyte antigen 75
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
MPZL1 myelin protein zero-like 1
MRPL19 mitochondrial ribosomal protein L19
MYC v-myc avian myelocytomatosis viral oncogene homolog
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDFIP1 Nedd4 family interacting protein 1
NEFH neurofilament, heavy polypeptide
NUP62 nucleoporin 62kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDZD8 PDZ domain containing 8
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PPARG peroxisome proliferator-activated receptor gamma
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIG peptidylprolyl isomerase G (cyclophilin G)
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
PTDSS1 phosphatidylserine synthase 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RPA1 replication protein A1, 70kDa
RPIA ribose 5-phosphate isomerase A
SEH1L SEH1-like (S. cerevisiae)
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35F2 solute carrier family 35, member F2
SPRY2 sprouty homolog 2 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TMEM126B transmembrane protein 126B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
UNC119B unc-119 homolog B (C. elegans)