BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH2073_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH2073_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADIRF adipogenesis regulatory factor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
BCR breakpoint cluster region
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
CAPG capping protein (actin filament), gelsolin-like
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDN3 claudin 3
CREB5 cAMP responsive element binding protein 5
CRP C-reactive protein, pentraxin-related
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EREG epiregulin
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
H1F0 H1 histone family, member 0
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6 interleukin 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KLK5 kallikrein-related peptidase 5
LCN2 lipocalin 2
LIF leukemia inhibitory factor
MAMLD1 mastermind-like domain containing 1
MICALL1 MICAL-like 1
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MSLN mesothelin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PADI2 peptidyl arginine deiminase, type II
PCP4 Purkinje cell protein 4
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIPK2 receptor-interacting serine-threonine kinase 2
RRAGD Ras-related GTP binding D
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK3 SIK family kinase 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
TGFA transforming growth factor, alpha
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASF1A anti-silencing function 1A histone chaperone
ATF5 activating transcription factor 5
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BST2 bone marrow stromal cell antigen 2
C1S complement component 1, s subcomponent
CALR calreticulin
CCNA2 cyclin A2
CCNF cyclin F
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CIRBP cold inducible RNA binding protein
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
COL7A1 collagen, type VII, alpha 1
CRYZ crystallin, zeta (quinone reductase)
CSRP1 cysteine and glycine-rich protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIO2 deiodinase, iodothyronine, type II
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FASTKD5 FAST kinase domains 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FYB FYN binding protein
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ITGA6 integrin, alpha 6
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LBH limb bud and heart development
LONP2 lon peptidase 2, peroxisomal
LPAR1 lysophosphatidic acid receptor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEGF9 multiple EGF-like-domains 9
MMP11 matrix metallopeptidase 11
MRPL19 mitochondrial ribosomal protein L19
NUP62 nucleoporin 62kDa
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PRKCB protein kinase C, beta
PRSS23 protease, serine, 23
PTPRC protein tyrosine phosphatase, receptor type, C
RBP1 retinol binding protein 1, cellular
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RPS11 ribosomal protein S11
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRGN serglycin
TAGLN transgelin
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM14A transmembrane protein 14A
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TXNDC9 thioredoxin domain containing 9
UBE3C ubiquitin protein ligase E3C
WNT5A wingless-type MMTV integration site family, member 5A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZMYND8 zinc finger, MYND-type containing 8