BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH1694_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH1694_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA10 annexin A10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE41 basic helix-loop-helix family, member e41
CASP10 caspase 10, apoptosis-related cysteine peptidase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLU clusterin
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EFNB2 ephrin-B2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP1 epithelial membrane protein 1
FHL1 four and a half LIM domains 1
GRB10 growth factor receptor-bound protein 10
H1FX H1 histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
JUN jun proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICALL1 MICAL-like 1
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SFRP1 secreted frizzled-related protein 1
SMC1A structural maintenance of chromosomes 1A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRG2 adhesion G protein-coupled receptor G2
ATP11B ATPase, class VI, type 11B
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BIRC5 baculoviral IAP repeat containing 5
BPIFA1 BPI fold containing family A, member 1
C1ORF116 chromosome 1 open reading frame 116
CCNF cyclin F
CD24 CD24 molecule
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL3 dihydropyrimidinase-like 3
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F12 coagulation factor XII (Hageman factor)
FAM98A family with sequence similarity 98, member A
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1R insulin-like growth factor 1 receptor
KDM5D lysine (K)-specific demethylase 5D
KRT23 keratin 23, type I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPT microtubule-associated protein tau
MATN2 matrilin 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2NL notch 2 N-terminal like
OLFM1 olfactomedin 1
PDGFA platelet-derived growth factor alpha polypeptide
PFN2 profilin 2
PRR7 proline rich 7 (synaptic)
RPL27A ribosomal protein L27a
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SET SET nuclear proto-oncogene
SFN stratifin
STXBP2 syntaxin binding protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TMF1 TATA element modulatory factor 1
TRIM22 tripartite motif containing 22
TUBA4A tubulin, alpha 4a
TYRP1 tyrosinase-related protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP9Y ubiquitin specific peptidase 9, Y-linked