BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_MCF7_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_MCF7_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CCNL1 cyclin L1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COG5 component of oligomeric golgi complex 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
FAM60A family with sequence similarity 60, member A
FN1 fibronectin 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
IVNS1ABP influenza virus NS1A binding protein
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RHOB ras homolog family member B
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOX4 SRY (sex determining region Y)-box 4
STC2 stanniocalcin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATF5 activating transcription factor 5
B3GNT1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
COL3A1 collagen, type III, alpha 1
CTTN cortactin
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ENDOD1 endonuclease domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FBXO9 F-box protein 9
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
HAL histidine ammonia-lyase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KRT1 keratin 1, type II
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYPD3 LY6/PLAUR domain containing 3
MAT2A methionine adenosyltransferase II, alpha
MLEC malectin
MXRA7 matrix-remodelling associated 7
OXTR oxytocin receptor
PHB prohibitin
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PTGES prostaglandin E synthase
RALGDS ral guanine nucleotide dissociation stimulator
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SCP2 sterol carrier protein 2
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WFS1 Wolfram syndrome 1 (wolframin)
ZC3HAV1 zinc finger CCCH-type, antiviral 1