BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_LOVO_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_LOVO_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FBXO11 F-box protein 11
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FOSL2 FOS-like antigen 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR6 lysophosphatidic acid receptor 6
LTBP2 latent transforming growth factor beta binding protein 2
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MAOB monoamine oxidase B
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MSMO1 methylsterol monooxygenase 1
MT1G metallothionein 1G
NANS N-acetylneuraminic acid synthase
NCF4 neutrophil cytosolic factor 4, 40kDa
NDEL1 nudE neurodevelopment protein 1-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP2 plakophilin 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEC24D SEC24 family member D
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SULF1 sulfatase 1
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPRSS3 transmembrane protease, serine 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZFPM2 zinc finger protein, FOG family member 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
CAST calpastatin
CCNA2 cyclin A2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CTSH cathepsin H
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
EIF4B eukaryotic translation initiation factor 4B
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FGB fibrinogen beta chain
FUS FUS RNA binding protein
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GCH1 GTP cyclohydrolase 1
GLB1L2 galactosidase, beta 1-like 2
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC1 histone deacetylase 1
HLA-C major histocompatibility complex, class I, C
HOXA10 homeobox A10
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
JADE2 jade family PHD finger 2
JAG2 jagged 2
KANK2 KN motif and ankyrin repeat domains 2
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LEPR leptin receptor
LIG1 ligase I, DNA, ATP-dependent
LY75 lymphocyte antigen 75
MAP3K4 mitogen-activated protein kinase kinase kinase 4
METRN meteorin, glial cell differentiation regulator
MGST2 microsomal glutathione S-transferase 2
MLEC malectin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NUP210 nucleoporin 210kDa
NUP62 nucleoporin 62kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTDSS1 phosphatidylserine synthase 1
RPA1 replication protein A1, 70kDa
RPL31 ribosomal protein L31
RRP1B ribosomal RNA processing 1B
SCAMP1 secretory carrier membrane protein 1
SEPP1 selenoprotein P, plasma, 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TCTN1 tectonic family member 1
TMEM109 transmembrane protein 109
TMEM50A transmembrane protein 50A
TMF1 TATA element modulatory factor 1
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM14 tripartite motif containing 14
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UBE3C ubiquitin protein ligase E3C
UBL3 ubiquitin-like 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WBSCR22 Williams Beuren syndrome chromosome region 22