BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HT29_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HT29_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACVR1 activin A receptor, type I
ANXA1 annexin A1
ANXA10 annexin A10
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAB39 calcium binding protein 39
CARS cysteinyl-tRNA synthetase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CSTA cystatin A (stefin A)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
EZR ezrin
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1A interleukin 1, alpha
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MOCOS molybdenum cofactor sulfurase
MT1F metallothionein 1F
MT1G metallothionein 1G
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NARS asparaginyl-tRNA synthetase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOBTB3 Rho-related BTB domain containing 3
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ATF5 activating transcription factor 5
AURKA aurora kinase A
B3GNT1
C2CD2 C2 calcium-dependent domain containing 2
CDC25A cell division cycle 25A
CKAP2 cytoskeleton associated protein 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H2AFX H2A histone family, member X
HMGN3 high mobility group nucleosomal binding domain 3
HOPX HOP homeobox
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
LBH limb bud and heart development
MMP12 matrix metallopeptidase 12
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
SCG2 secretogranin II
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
ZC3HAV1 zinc finger CCCH-type, antiviral 1