BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HT115_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HT115_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAT1 adenosine deaminase, tRNA-specific 1
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CARS cysteinyl-tRNA synthetase
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN4 claudin 4
CREB5 cAMP responsive element binding protein 5
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DNMBP dynamin binding protein
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
ELF5 E74-like factor 5 (ets domain transcription factor)
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
MYOF myoferlin
NAMPT nicotinamide phosphoribosyltransferase
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH2NL notch 2 N-terminal like
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIAH2 siah E3 ubiquitin protein ligase 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SSFA2 sperm specific antigen 2
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF4 transmembrane 4 L six family member 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
B3GNT1
BAG3 BCL2-associated athanogene 3
C3 complement component 3
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
COX11 COX11 cytochrome c oxidase copper chaperone
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
DACH1 dachshund family transcription factor 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTX4 deltex 4, E3 ubiquitin ligase
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FYB FYN binding protein
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITM2C integral membrane protein 2C
LEPROT leptin receptor overlapping transcript
LPL lipoprotein lipase
MCAM melanoma cell adhesion molecule
MDFIC MyoD family inhibitor domain containing
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MLEC malectin
NARF nuclear prelamin A recognition factor
NOTCH1 notch 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PSRC1 proline/serine-rich coiled-coil 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RXRA retinoid X receptor, alpha
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
THY1 Thy-1 cell surface antigen
TNS1 tensin 1
TRIM22 tripartite motif containing 22
TSPAN13 tetraspanin 13
UNC119B unc-119 homolog B (C. elegans)