BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HCT116_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HCT116_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLDN4 claudin 4
COL11A1 collagen, type XI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR2 early growth response 2
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
F11R F11 receptor
FHL2 four and a half LIM domains 2
FOSL2 FOS-like antigen 2
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GPX2 glutathione peroxidase 2
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INHBA inhibin, beta A
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
MAOA monoamine oxidase A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
ORM1 orosomucoid 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRR15L proline rich 15-like
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TERF2IP telomeric repeat binding factor 2, interacting protein
TF transferrin
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF165 zinc finger protein 165
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AK1 adenylate kinase 1
ATMIN ATM interactor
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP1 cysteine and glycine-rich protein 1
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
ECI2 enoyl-CoA delta isomerase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FCGBP Fc fragment of IgG binding protein
GNPDA1 glucosamine-6-phosphate deaminase 1
GYS1 glycogen synthase 1 (muscle)
HOXA10 homeobox A10
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IL2RG interleukin 2 receptor, gamma
ITGB5 integrin, beta 5
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LBR lamin B receptor
LONP2 lon peptidase 2, peroxisomal
LPCAT1 lysophosphatidylcholine acyltransferase 1
LY75 lymphocyte antigen 75
MACF1 microtubule-actin crosslinking factor 1
MCAM melanoma cell adhesion molecule
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPZL1 myelin protein zero-like 1
MRPL34 mitochondrial ribosomal protein L34
MXRA7 matrix-remodelling associated 7
NUP62 nucleoporin 62kDa
OLFM1 olfactomedin 1
OXA1L oxidase (cytochrome c) assembly 1-like
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRPF4 pre-mRNA processing factor 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
UNC119B unc-119 homolog B (C. elegans)