BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HCC515_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_HCC515_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ACBD3 acyl-CoA binding domain containing 3
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR3 early growth response 3
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAMLD1 mastermind-like domain containing 1
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOCOS molybdenum cofactor sulfurase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
OLFML2A olfactomedin-like 2A
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PGF placental growth factor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDCBP syndecan binding protein (syntenin)
SEC24D SEC24 family member D
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
TARS threonyl-tRNA synthetase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ATF5 activating transcription factor 5
B3GNT1
BCHE butyrylcholinesterase
CCND1 cyclin D1
CD200 CD200 molecule
CDC25A cell division cycle 25A
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CIAPIN1 cytokine induced apoptosis inhibitor 1
CP ceruloplasmin (ferroxidase)
CXCL14 chemokine (C-X-C motif) ligand 14
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HMGN3 high mobility group nucleosomal binding domain 3
HOXA5 homeobox A5
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MCM3 minichromosome maintenance complex component 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
PEBP1 phosphatidylethanolamine binding protein 1
POSTN periostin, osteoblast specific factor
PRSS23 protease, serine, 23
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNASET2 ribonuclease T2
SDC2 syndecan 2
SEPW1 selenoprotein W, 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10