BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_H1299_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_H1299_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCAM basal cell adhesion molecule (Lutheran blood group)
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CLDN3 claudin 3
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DSP desmoplakin
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
EGF epidermal growth factor
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
HACD3 3-hydroxyacyl-CoA dehydratase 3
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0196 KIAA0196
KLF7 Kruppel-like factor 7 (ubiquitous)
MT1E metallothionein 1E
MT1F metallothionein 1F
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1B myosin IB
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
PEG10 paternally expressed 10
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULF1 sulfatase 1
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM176B transmembrane protein 176B
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADAM28 ADAM metallopeptidase domain 28
ANXA6 annexin A6
ANXA7 annexin A7
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHPT1 choline phosphotransferase 1
CORO1C coronin, actin binding protein, 1C
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP3 epithelial membrane protein 3
FAM134C family with sequence similarity 134, member C
FASTKD5 FAST kinase domains 5
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KCTD5 potassium channel tetramerization domain containing 5
KIF20A kinesin family member 20A
LBR lamin B receptor
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MPHOSPH9 M-phase phosphoprotein 9
MRPS30 mitochondrial ribosomal protein S30
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
PLK1 polo-like kinase 1
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
PWP1 PWP1 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM34 RNA binding motif protein 34
RPIA ribose 5-phosphate isomerase A
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SACS sacsin molecular chaperone
SFRP1 secreted frizzled-related protein 1
SIDT2 SID1 transmembrane family, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STOM stomatin
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNL4A thioredoxin-like 4A
UBE2S ubiquitin-conjugating enzyme E2S
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1