BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_EFO27_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_EFO27_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C3 aldo-keto reductase family 1, member C3
AMOTL2 angiomotin like 2
ANXA1 annexin A1
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
C5AR1 complement component 5a receptor 1
CA4 carbonic anhydrase IV
CCNA1 cyclin A1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CLU clusterin
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYTIP cytohesin 1 interacting protein
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FAM134B family with sequence similarity 134, member B
FKBP11 FK506 binding protein 11, 19 kDa
FMOD fibromodulin
FOSL2 FOS-like antigen 2
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL6 interleukin 6
JCHAIN joining chain of multimeric IgA and IgM
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LTF lactotransferrin
LXN latexin
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PAX8 paired box 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLTP phospholipid transfer protein
PODXL podocalyxin-like
POU2AF1 POU class 2 associating factor 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RGS5 regulator of G-protein signaling 5
S100A2 S100 calcium binding protein A2
SARS seryl-tRNA synthetase
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A46 solute carrier family 25, member 46
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCEA1 transcription elongation factor A (SII), 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TLR4 toll-like receptor 4
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZEB2 zinc finger E-box binding homeobox 2
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ARID4B AT rich interactive domain 4B (RBP1-like)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BCHE butyrylcholinesterase
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CKAP2 cytoskeleton associated protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
F2R coagulation factor II (thrombin) receptor
FAM69A family with sequence similarity 69, member A
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HLA-DOB major histocompatibility complex, class II, DO beta
HOXC6 homeobox C6
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KRT23 keratin 23, type I
LBH limb bud and heart development
LBR lamin B receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS2 Meis homeobox 2
NKG7 natural killer cell granule protein 7
NR2F2 nuclear receptor subfamily 2, group F, member 2
PENK proenkephalin
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCB protein kinase C, beta
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RBP1 retinol binding protein 1, cellular
RNF43 ring finger protein 43
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM123 transmembrane protein 123
TMEM97 transmembrane protein 97
TRIM14 tripartite motif containing 14
XCL1 chemokine (C motif) ligand 1
ZBTB18 zinc finger and BTB domain containing 18
ZBTB20 zinc finger and BTB domain containing 20
ZNF652 zinc finger protein 652