BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_CORL23_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

146 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_CORL23_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRE5 adhesion G protein-coupled receptor E5
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCLAF1 BCL2-associated transcription factor 1
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
CCR7 chemokine (C-C motif) receptor 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EPN2 epsin 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FLNA filamin A, alpha
FLNB filamin B, beta
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LEF1 lymphoid enhancer-binding factor 1
MAP1B microtubule-associated protein 1B
MBNL1 muscleblind-like splicing regulator 1
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
NAMPT nicotinamide phosphoribosyltransferase
NBPF10 neuroblastoma breakpoint family, member 10
NFIL3 nuclear factor, interleukin 3 regulated
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOB ras homolog family member B
RPL36 ribosomal protein L36
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
STAT1 signal transducer and activator of transcription 1, 91kDa
STK26 serine/threonine protein kinase 26
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
TICAM1 toll-like receptor adaptor molecule 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AMACR alpha-methylacyl-CoA racemase
ANOS1 anosmin 1
ATF5 activating transcription factor 5
B3GNT1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCNF cyclin F
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COG7 component of oligomeric golgi complex 7
CORO1A coronin, actin binding protein, 1A
DENND1B DENN/MADD domain containing 1B
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GJA1 gap junction protein, alpha 1, 43kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1R insulin-like growth factor 1 receptor
LPCAT1 lysophosphatidylcholine acyltransferase 1
MSMB microseminoprotein, beta-
NARFL nuclear prelamin A recognition factor-like
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHA5 pleckstrin homology domain containing, family A member 5
PXDN peroxidasin
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SOX11 SRY (sex determining region Y)-box 11
SRI sorcin
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOR1A torsin family 1, member A (torsin A)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VLDLR very low density lipoprotein receptor