BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_CL34_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_CL34_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL6 B-cell CLL/lymphoma 6
C1S complement component 1, s subcomponent
C3 complement component 3
CARS cysteinyl-tRNA synthetase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CFB complement factor B
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSE dermatan sulfate epimerase
DST dystonin
DUSP1 dual specificity phosphatase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IGF1 insulin-like growth factor 1 (somatomedin C)
ITM2A integral membrane protein 2A
KRT18 keratin 18, type I
LPAR1 lysophosphatidic acid receptor 1
LXN latexin
MGP matrix Gla protein
MT1E metallothionein 1E
MT1F metallothionein 1F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUT methylmalonyl CoA mutase
MYO10 myosin X
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NNMT nicotinamide N-methyltransferase
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRL platelet-derived growth factor receptor-like
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PLVAP plasmalemma vesicle associated protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFTN1 raftlin, lipid raft linker 1
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TLK2 tousled-like kinase 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TSG101 tumor susceptibility 101
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AMPD2 adenosine monophosphate deaminase 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CANT1 calcium activated nucleotidase 1
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK6 cyclin-dependent kinase 6
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CXADR coxsackie virus and adenovirus receptor
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPH2 DPH2 homolog (S. cerevisiae)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMG20B high mobility group 20B
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
LEF1 lymphoid enhancer-binding factor 1
LRP4 low density lipoprotein receptor-related protein 4
MFSD12 major facilitator superfamily domain containing 12
MYB v-myb avian myeloblastosis viral oncogene homolog
NARF nuclear prelamin A recognition factor
NT5DC2 5'-nucleotidase domain containing 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDPN podoplanin
PF4 platelet factor 4
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PROM1 prominin 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SHB Src homology 2 domain containing adaptor protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
TMEM45A transmembrane protein 45A
TRIM2 tripartite motif containing 2
TUBA4A tubulin, alpha 4a
TYRP1 tyrosinase-related protein 1
XIST X inactive specific transcript (non-protein coding)