BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_AGS_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_AGS_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRF5 adhesion G protein-coupled receptor F5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOLD1 apolipoprotein L domain containing 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CCND2 cyclin D2
CCNI cyclin I
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN18 claudin 18
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CTH cystathionine gamma-lyase
CTSH cathepsin H
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFS embryonal Fyn-associated substrate
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
EPHA3 EPH receptor A3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GALC galactosylceramidase
GNAS GNAS complex locus
GRB10 growth factor receptor-bound protein 10
GSTA4 glutathione S-transferase alpha 4
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IRF9 interferon regulatory factor 9
JARID2 jumonji, AT rich interactive domain 2
JMJD1C jumonji domain containing 1C
KCNK1 potassium channel, two pore domain subfamily K, member 1
LUM lumican
LY6D lymphocyte antigen 6 complex, locus D
LYZ lysozyme
MBNL2 muscleblind-like splicing regulator 2
METRN meteorin, glial cell differentiation regulator
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NAMPT nicotinamide phosphoribosyltransferase
NCOA3 nuclear receptor coactivator 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK5 proprotein convertase subtilisin/kexin type 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAC8 placenta-specific 8
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS1 regulator of G-protein signaling 1
S100P S100 calcium binding protein P
SIK1 salt-inducible kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TACSTD2 tumor-associated calcium signal transducer 2
TARS threonyl-tRNA synthetase
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AQP3 aquaporin 3 (Gill blood group)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCNF cyclin F
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CLDN10 claudin 10
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GMPR guanosine monophosphate reductase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GYG1 glycogenin 1
H3F3B H3 histone, family 3B (H3.3B)
HSPA8 heat shock 70kDa protein 8
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0125 KIAA0125
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100505650 uncharacterized LOC100505650
LYPD1 LY6/PLAUR domain containing 1
MUC16 mucin 16, cell surface associated
NNMT nicotinamide N-methyltransferase
NRCAM neuronal cell adhesion molecule
OSBPL3 oxysterol binding protein-like 3
OXTR oxytocin receptor
PDGFC platelet derived growth factor C
PIP prolactin-induced protein
PRDX4 peroxiredoxin 4
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RPL27A ribosomal protein L27a
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SEPP1 selenoprotein P, plasma, 1
SLPI secretory leukocyte peptidase inhibitor
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMOD1 tropomodulin 1
TRIM29 tripartite motif containing 29
TUBB4B tubulin, beta 4B class IVb
WFDC2 WAP four-disulfide core domain 2