BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_A673_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_A673_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ADGRL4 adhesion G protein-coupled receptor L4
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
ANXA2 annexin A2
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
BMP7 bone morphogenetic protein 7
C6ORF48 chromosome 6 open reading frame 48
CAPN2 calpain 2, (m/II) large subunit
CARS cysteinyl-tRNA synthetase
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CHN2 chimerin 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL15A1 collagen, type XV, alpha 1
COL9A3 collagen, type IX, alpha 3
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPRS glutamyl-prolyl-tRNA synthetase
ETV5 ets variant 5
EXT1 exostosin glycosyltransferase 1
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
GREB1 growth regulation by estrogen in breast cancer 1
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
INHBE inhibin, beta E
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LIMA1 LIM domain and actin binding 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MOCOS molybdenum cofactor sulfurase
MT1G metallothionein 1G
MUC4 mucin 4, cell surface associated
NANS N-acetylneuraminic acid synthase
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG3 paternally expressed 3
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SDF2L1 stromal cell-derived factor 2-like 1
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STC2 stanniocalcin 2
SYT17 synaptotagmin XVII
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
TNNC1 troponin C type 1 (slow)
TRBC1 T cell receptor beta constant 1
TRIB3 tribbles pseudokinase 3
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ADD1 adducin 1 (alpha)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AQP1 aquaporin 1 (Colton blood group)
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL2A1 BCL2-related protein A1
C1ORF106 chromosome 1 open reading frame 106
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPZB capping protein (actin filament) muscle Z-line, beta
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CSRP1 cysteine and glycine-rich protein 1
CYB5A cytochrome b5 type A (microsomal)
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAPK1 death-associated protein kinase 1
DPYSL3 dihydropyrimidinase-like 3
EFNB2 ephrin-B2
ELN elastin
FAR2 fatty acyl CoA reductase 2
FGFR3 fibroblast growth factor receptor 3
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HMGB3 high mobility group box 3
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IL6R interleukin 6 receptor
KIAA0232 KIAA0232
LEFTY1 left-right determination factor 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAEA macrophage erythroblast attacher
MFSD10 major facilitator superfamily domain containing 10
MN1 meningioma (disrupted in balanced translocation) 1
PAPD7 PAP associated domain containing 7
PCGF3 polycomb group ring finger 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFN2 profilin 2
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PLK1 polo-like kinase 1
PLS3 plastin 3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSRC1 proline/serine-rich coiled-coil 1
RNF4 ring finger protein 4
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SP110 SP110 nuclear body protein
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
SST somatostatin
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TOMM34 translocase of outer mitochondrial membrane 34
TSPAN3 tetraspanin 3
TXNDC9 thioredoxin domain containing 9
UBE3C ubiquitin protein ligase E3C
WBP5 WW domain binding protein 5