BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_A549_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_A549_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CLIC5 chloride intracellular channel 5
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DGKZ diacylglycerol kinase, zeta
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
ENG endoglin
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GAS6 growth arrest-specific 6
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
LGALS4 lectin, galactoside-binding, soluble, 4
LRMP lymphoid-restricted membrane protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD10 major facilitator superfamily domain containing 10
MMP12 matrix metallopeptidase 12
MYO15B myosin XVB
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSBPL10 oxysterol binding protein-like 10
PDE4C phosphodiesterase 4C, cAMP-specific
PLD3 phospholipase D family, member 3
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKD2 protein kinase D2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SCGB1D2 secretoglobin, family 1D, member 2
SFN stratifin
STC1 stanniocalcin 1
TLR4 toll-like receptor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB1 tribbles pseudokinase 1
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
AKAP7 A kinase (PRKA) anchor protein 7
AMD1 adenosylmethionine decarboxylase 1
ANXA5 annexin A5
ANXA7 annexin A7
ARF4 ADP-ribosylation factor 4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASPH aspartate beta-hydroxylase
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALU calumenin
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNA2 cyclin A2
CCNC cyclin C
CCNG1 cyclin G1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COPS4 COP9 signalosome subunit 4
CORO1C coronin, actin binding protein, 1C
COX11 COX11 cytochrome c oxidase copper chaperone
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSB cathepsin B
DCK deoxycytidine kinase
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
ECI2 enoyl-CoA delta isomerase 2
EMP3 epithelial membrane protein 3
FASTKD5 FAST kinase domains 5
FBXO21 F-box protein 21
FCGBP Fc fragment of IgG binding protein
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GDE1 glycerophosphodiester phosphodiesterase 1
GDI2 GDP dissociation inhibitor 2
GOLGA7 golgin A7
GRSF1 G-rich RNA sequence binding factor 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAT1 histone acetyltransferase 1
HDAC2 histone deacetylase 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLTF helicase-like transcription factor
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSPA14 heat shock 70kDa protein 14
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IPO5 importin 5
IQGAP2 IQ motif containing GTPase activating protein 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0391 KIAA0391
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LYPLA1 lysophospholipase I
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NUSAP1 nucleolar and spindle associated protein 1
OXTR oxytocin receptor
PALLD palladin, cytoskeletal associated protein
PGK1 phosphoglycerate kinase 1
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPP6C protein phosphatase 6, catalytic subunit
PRDX3 peroxiredoxin 3
PRDX4 peroxiredoxin 4
PRKCA protein kinase C, alpha
PRKD3 protein kinase D3
PRNP prion protein
PROM1 prominin 1
PSPH phosphoserine phosphatase
RAB22A RAB22A, member RAS oncogene family
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOA ras homolog family member A
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC23A Sec23 homolog A (S. cerevisiae)
SEC23B Sec23 homolog B (S. cerevisiae)
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SNX6 sorting nexin 6
SORD sorbitol dehydrogenase
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRP72 signal recognition particle 72kDa
SRPRB signal recognition particle receptor, B subunit
SRPX sushi-repeat containing protein, X-linked
SSR1 signal sequence receptor, alpha
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
SUB1 SUB1 homolog (S. cerevisiae)
TBC1D4 TBC1 domain family, member 4
TM9SF2 transmembrane 9 superfamily member 2
TMEM135 transmembrane protein 135
TMEM168 transmembrane protein 168
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE3C ubiquitin protein ligase E3C
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCAN versican
WRB tryptophan rich basic protein
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZMYND11 zinc finger, MYND-type containing 11