BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_A375_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_A375_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
C2CD2 C2 calcium-dependent domain containing 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CD38 CD38 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEP57 centrosomal protein 57kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBL cordon-bleu WH2 repeat protein
CPB1 carboxypeptidase B1 (tissue)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
DBT dihydrolipoamide branched chain transacylase E2
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLD dihydrolipoamide dehydrogenase
EREG epiregulin
FAM134B family with sequence similarity 134, member B
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLDC glycine dehydrogenase (decarboxylating)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HIST1H1C histone cluster 1, H1c
HMGA1 high mobility group AT-hook 1
HOXC6 homeobox C6
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT6B keratin 6B, type II
LUM lumican
MCL1 myeloid cell leukemia 1
MMP3 matrix metallopeptidase 3
MOCOS molybdenum cofactor sulfurase
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBPF10 neuroblastoma breakpoint family, member 10
NFIL3 nuclear factor, interleukin 3 regulated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RIOK3 RIO kinase 3
RPL37A ribosomal protein L37a
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
TLR4 toll-like receptor 4
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSPAN8 tetraspanin 8
USP1 ubiquitin specific peptidase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZEB2 zinc finger E-box binding homeobox 2
ZNF721 zinc finger protein 721

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTG2 actin, gamma 2, smooth muscle, enteric
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AURKA aurora kinase A
C3 complement component 3
CA12 carbonic anhydrase XII
CAST calpastatin
CCNF cyclin F
CKAP4 cytoskeleton-associated protein 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
HHEX hematopoietically expressed homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100505650 uncharacterized LOC100505650
MEIS1 Meis homeobox 1
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MYH11 myosin, heavy chain 11, smooth muscle
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUP62 nucleoporin 62kDa
PAM peptidylglycine alpha-amidating monooxygenase
PDIA3 protein disulfide isomerase family A, member 3
PNMA1 paraneoplastic Ma antigen 1
PSCA prostate stem cell antigen
PWP1 PWP1 homolog (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STK39 serine threonine kinase 39
TARBP1 TAR (HIV-1) RNA binding protein 1
TEX10 testis expressed 10
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)