BRD-K43389698_BMS-387032_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K43389698_BMS-387032_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CD3D CD3d molecule, delta (CD3-TCR complex)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CFH complement factor H
CFI complement factor I
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
COMP cartilage oligomeric matrix protein
CTSV cathepsin V
CTTN cortactin
DLK1 delta-like 1 homolog (Drosophila)
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR2 early growth response 2
ELN elastin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOS FBJ murine osteosarcoma viral oncogene homolog
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
GYG2 glycogenin 2
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LOC100272216 uncharacterized LOC100272216
MAOA monoamine oxidase A
MMP1 matrix metallopeptidase 1
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLIN1 perilipin 1
PLLP plasmolipin
PLVAP plasmalemma vesicle associated protein
PROS1 protein S (alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLIT3 slit homolog 3 (Drosophila)
SMYD3 SET and MYND domain containing 3
THBS4 thrombospondin 4
TMSB15A thymosin beta 15a
TNS1 tensin 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AHNAK AHNAK nucleoprotein
ARF6 ADP-ribosylation factor 6
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP55 centrosomal protein 55kDa
CLTA clathrin, light chain A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST1 cystatin SN
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMBP dynamin binding protein
DUSP6 dual specificity phosphatase 6
EIF4E eukaryotic translation initiation factor 4E
ELOVL6 ELOVL fatty acid elongase 6
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
ITGA6 integrin, alpha 6
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5D lysine (K)-specific demethylase 5D
LASP1 LIM and SH3 protein 1
LMNB1 lamin B1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NOTCH2 notch 2
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
RNPS1 RNA binding protein S1, serine-rich domain
SET SET nuclear proto-oncogene
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STX3 syntaxin 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM2 translocation associated membrane protein 2
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VCAN versican
YBX3 Y box binding protein 3