BRD-K43389698_BMS-387032_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K43389698_BMS-387032_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BHLHE40 basic helix-loop-helix family, member e40
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD9 CD9 molecule
CD99 CD99 molecule
CEP70 centrosomal protein 70kDa
CFB complement factor B
CFI complement factor I
CLEC3B C-type lectin domain family 3, member B
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTSK cathepsin K
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
DYNLT3 dynein, light chain, Tctex-type 3
ECM1 extracellular matrix protein 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLTF helicase-like transcription factor
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KDM3A lysine (K)-specific demethylase 3A
LAMP2 lysosomal-associated membrane protein 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NPR1 natriuretic peptide receptor 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN1 perilipin 1
PPAP2B phosphatidic acid phosphatase type 2B
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SPARCL1 SPARC-like 1 (hevin)
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TMEM45A transmembrane protein 45A
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AKAP1 A kinase (PRKA) anchor protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK7 cyclin-dependent kinase 7
CLTA clathrin, light chain A
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ERH enhancer of rudimentary homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
GCH1 GTP cyclohydrolase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITPKB inositol-trisphosphate 3-kinase B
JADE2 jade family PHD finger 2
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LBR lamin B receptor
LMNB1 lamin B1
MALL mal, T-cell differentiation protein-like
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MICALL1 MICAL-like 1
MRPL12 mitochondrial ribosomal protein L12
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAE1 ribonucleic acid export 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RNPS1 RNA binding protein S1, serine-rich domain
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SFN stratifin
SLIRP SRA stem-loop interacting RNA binding protein
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPIN TIMELESS interacting protein
TMEM5 transmembrane protein 5
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TRIP6 thyroid hormone receptor interactor 6
TXLNA taxilin alpha
TYMS thymidylate synthetase
WDR6 WD repeat domain 6
WEE1 WEE1 G2 checkpoint kinase
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC6 zinc finger, DHHC-type containing 6