BRD-K43389698_BMS-387032_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K43389698_BMS-387032_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANO1 anoctamin 1, calcium activated chloride channel
ANOS1 anosmin 1
ASPN asporin
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
CD36 CD36 molecule (thrombospondin receptor)
COL11A1 collagen, type XI, alpha 1
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CTTN cortactin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNM1L dynamin 1-like
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IDE insulin-degrading enzyme
IFI6 interferon, alpha-inducible protein 6
INHBA inhibin, beta A
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCUR1 mitochondrial calcium uniporter regulator 1
MDFIC MyoD family inhibitor domain containing
NCF2 neutrophil cytosolic factor 2
NTS neurotensin
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSR1 signal sequence receptor, alpha
SYNM synemin, intermediate filament protein
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TRIB2 tribbles pseudokinase 2

decreased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AMOTL2 angiomotin like 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CCNE2 cyclin E2
CCNL1 cyclin L1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN4 claudin 4
CRISP3 cysteine-rich secretory protein 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FASTKD5 FAST kinase domains 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
KLF10 Kruppel-like factor 10
KRT23 keratin 23, type I
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MED17 mediator complex subunit 17
MSL2 male-specific lethal 2 homolog (Drosophila)
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PER2 period circadian clock 2
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RERE arginine-glutamic acid dipeptide (RE) repeats
RPP38 ribonuclease P/MRP 38kDa subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SPATA5L1 spermatogenesis associated 5-like 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TOB2 transducer of ERBB2, 2
TRIB3 tribbles pseudokinase 3
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
UGCG UDP-glucose ceramide glucosyltransferase
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217