BRD-K43389698_BMS-387032_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

287 genes differentially expressed following the BRD-K43389698_BMS-387032_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMPD3 adenosine monophosphate deaminase 3
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
ATG12 autophagy related 12
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CAV2 caveolin 2
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CETN2 centrin, EF-hand protein, 2
CLU clusterin
COCH cochlin
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CTTN cortactin
CYBRD1 cytochrome b reductase 1
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DPYSL3 dihydropyrimidinase-like 3
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
G0S2 G0/G1 switch 2
GDI1 GDP dissociation inhibitor 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HP haptoglobin
HRSP12 heat-responsive protein 12
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGLL1 immunoglobulin lambda-like polypeptide 1
ISG15 ISG15 ubiquitin-like modifier
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP3 lysosomal-associated membrane protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
LTA4H leukotriene A4 hydrolase
LYN LYN proto-oncogene, Src family tyrosine kinase
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MSLN mesothelin
MSRB1 methionine sulfoxide reductase B1
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
NUCB1 nucleobindin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKM phosphofructokinase, muscle
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLTP phospholipid transfer protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SNX10 sorting nexin 10
SORT1 sortilin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPGS2 tubulin polyglutamylase complex subunit 2
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP7 vesicle-associated membrane protein 7
WFDC2 WAP four-disulfide core domain 2
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKAP1 A kinase (PRKA) anchor protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARF6 ADP-ribosylation factor 6
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C14ORF132 chromosome 14 open reading frame 132
C14ORF169 chromosome 14 open reading frame 169
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP7 charged multivesicular body protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSNK1D casein kinase 1, delta
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DUSP7 dual specificity phosphatase 7
EFNA4 ephrin-A4
ERBB2 erb-b2 receptor tyrosine kinase 2
FASTKD5 FAST kinase domains 5
FBL fibrillarin
FCGBP Fc fragment of IgG binding protein
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPATCH8 G patch domain containing 8
GRB10 growth factor receptor-bound protein 10
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INHBB inhibin, beta B
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MB myoglobin
MED1 mediator complex subunit 1
METTL3 methyltransferase like 3
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB14 RAB14, member RAS oncogene family
RIN2 Ras and Rab interactor 2
RNF139 ring finger protein 139
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL39L ribosomal protein L39-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SASH1 SAM and SH3 domain containing 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SMAD1 SMAD family member 1
STMN2 stathmin 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBX3 T-box 3
TFAM transcription factor A, mitochondrial
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOX3 TOX high mobility group box family member 3
TSPYL4 TSPY-like 4
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UCK2 uridine-cytidine kinase 2
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VGLL4 vestigial-like family member 4
WDR82 WD repeat domain 82
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB10 zinc finger and BTB domain containing 10
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF217 zinc finger protein 217