BRD-K43389698_BMS-387032_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K43389698_BMS-387032_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADAM28 ADAM metallopeptidase domain 28
ADIRF adipogenesis regulatory factor
ADK adenosine kinase
BANK1 B-cell scaffold protein with ankyrin repeats 1
CAV2 caveolin 2
CDR2L cerebellar degeneration-related protein 2-like
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
COL10A1 collagen, type X, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COMP cartilage oligomeric matrix protein
CRLF1 cytokine receptor-like factor 1
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CYBB cytochrome b-245, beta polypeptide
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNB5 guanine nucleotide binding protein (G protein), beta 5
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM3 intercellular adhesion molecule 3
IDO1 indoleamine 2,3-dioxygenase 1
ITM2A integral membrane protein 2A
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAMA5 laminin, alpha 5
LIMCH1 LIM and calponin homology domains 1
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MDFIC MyoD family inhibitor domain containing
MMP9 matrix metallopeptidase 9
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMU neuromedin U
NPR3 natriuretic peptide receptor 3
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PLS3 plastin 3
PRDX3 peroxiredoxin 3
RAB13 RAB13, member RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEPW1 selenoprotein W, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STEAP3 STEAP family member 3, metalloreductase
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNGR2 synaptogyrin 2
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP1 A kinase (PRKA) anchor protein 1
APOLD1 apolipoprotein L domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATXN7 ataxin 7
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CCNL1 cyclin L1
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
EGR2 early growth response 2
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FBXL12 F-box and leucine-rich repeat protein 12
FBXL14 F-box and leucine-rich repeat protein 14
FEM1B fem-1 homolog b (C. elegans)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXG1 forkhead box G1
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MTF2 metal response element binding transcription factor 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA2 nuclear receptor coactivator 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NXT1 nuclear transport factor 2-like export factor 1
OXTR oxytocin receptor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PSRC1 proline/serine-rich coiled-coil 1
PTRH2 peptidyl-tRNA hydrolase 2
PUF60 poly-U binding splicing factor 60KDa
RBM15 RNA binding motif protein 15
RPL37A ribosomal protein L37a
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SASH1 SAM and SH3 domain containing 1
SATB2 SATB homeobox 2
SCAND1 SCAN domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TMEM70 transmembrane protein 70
TSC22D2 TSC22 domain family, member 2
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2