BRD-K43389675_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K43389675_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
CCND2 cyclin D2
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CHMP5 charged multivesicular body protein 5
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CTSV cathepsin V
DHCR24 24-dehydrocholesterol reductase
DSE dermatan sulfate epimerase
EID1 EP300 interacting inhibitor of differentiation 1
EXPH5 exophilin 5
FOLR1 folate receptor 1 (adult)
GLUL glutamate-ammonia ligase
GPC4 glypican 4
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL7R interleukin 7 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LDOC1 leucine zipper, down-regulated in cancer 1
LUM lumican
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
NTS neurotensin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PERP PERP, TP53 apoptosis effector
PLCB4 phospholipase C, beta 4
RAB31 RAB31, member RAS oncogene family
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SSBP2 single-stranded DNA binding protein 2
STC1 stanniocalcin 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TWF1 twinfilin actin binding protein 1
VIM vimentin
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARG1 arginase 1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL6 B-cell CLL/lymphoma 6
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
CALML5 calmodulin-like 5
CCNL1 cyclin L1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CSRP1 cysteine and glycine-rich protein 1
CTSG cathepsin G
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FASTKD5 FAST kinase domains 5
FCGBP Fc fragment of IgG binding protein
FEM1B fem-1 homolog b (C. elegans)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
GABPB1 GA binding protein transcription factor, beta subunit 1
GGNBP2 gametogenetin binding protein 2
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HRH1 histamine receptor H1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KCTD12 potassium channel tetramerization domain containing 12
KDM3A lysine (K)-specific demethylase 3A
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LIPG lipase, endothelial
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MMP7 matrix metallopeptidase 7
MTF2 metal response element binding transcription factor 2
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OSER1 oxidative stress responsive serine-rich 1
PARP2 poly (ADP-ribose) polymerase 2
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLAC8 placenta-specific 8
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PTX3 pentraxin 3, long
RBM39 RNA binding motif protein 39
RBM7 RNA binding motif protein 7
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RNMT RNA (guanine-7-) methyltransferase
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SCAF8 SR-related CTD-associated factor 8
SECISBP2L SECIS binding protein 2-like
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC38A2 solute carrier family 38, member 2
SMAD1 SMAD family member 1
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TBPL1 TBP-like 1
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
USP3 ubiquitin specific peptidase 3
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2