BRD-K43068349_AMG 9810_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-K43068349_AMG 9810_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACTN1 actinin, alpha 1
ANXA1 annexin A1
COLEC12 collectin sub-family member 12
EIF4A1 eukaryotic translation initiation factor 4A1
FN1 fibronectin 1
FRY furry homolog (Drosophila)
GREM1 gremlin 1, DAN family BMP antagonist
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP5 insulin-like growth factor binding protein 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
PELI1 pellino E3 ubiquitin protein ligase 1
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
SLC38A2 solute carrier family 38, member 2
SRSF7 serine/arginine-rich splicing factor 7
SULF1 sulfatase 1
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM2 tripartite motif containing 2
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
AKAP8L A kinase (PRKA) anchor protein 8-like
BST2 bone marrow stromal cell antigen 2
CCL5 chemokine (C-C motif) ligand 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TXNIP thioredoxin interacting protein