BRD-K43068349_AMG 9810_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K43068349_AMG 9810_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
ARG2 arginase 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN8 claudin 8
CP ceruloplasmin (ferroxidase)
CRELD2 cysteine-rich with EGF-like domains 2
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAP death-associated protein
DAXX death-domain associated protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EHF ets homologous factor
ENO2 enolase 2 (gamma, neuronal)
FAM162A family with sequence similarity 162, member A
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FZD1 frizzled class receptor 1
GALC galactosylceramidase
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSDMB gasdermin B
H1FX H1 histone family, member X
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA4 heat shock 70kDa protein 4
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KLF9 Kruppel-like factor 9
LCN2 lipocalin 2
LOXL2 lysyl oxidase-like 2
LPAR2 lysophosphatidic acid receptor 2
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MYOF myoferlin
MYRF myelin regulatory factor
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM1 PDZ and LIM domain 1
PDZK1IP1 PDZK1 interacting protein 1
PGK1 phosphoglycerate kinase 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLXNB2 plexin B2
PON3 paraoxonase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRK protein tyrosine phosphatase, receptor type, K
RAB25 RAB25, member RAS oncogene family
RAI14 retinoic acid induced 14
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPAG4 sperm associated antigen 4
SST somatostatin
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNGR1 synaptogyrin 1
TBXA2R thromboxane A2 receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKAP8 A kinase (PRKA) anchor protein 8
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
DACH1 dachshund family transcription factor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
KCTD12 potassium channel tetramerization domain containing 12
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTF2 metal response element binding transcription factor 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH9 protocadherin 9
PRMT1 protein arginine methyltransferase 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
QDPR quinoid dihydropteridine reductase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP1 retinol binding protein 1, cellular
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR3 small proline-rich protein 3
SRSF3 serine/arginine-rich splicing factor 3
TXNDC9 thioredoxin domain containing 9