BRD-K43068349_AMG 9810_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K43068349_AMG 9810_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACADVL acyl-CoA dehydrogenase, very long chain
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
BANK1 B-cell scaffold protein with ankyrin repeats 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA9 carbonic anhydrase IX
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD40 CD40 molecule, TNF receptor superfamily member 5
CLU clusterin
COL4A5 collagen, type IV, alpha 5
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FOXO1 forkhead box O1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
LEFTY1 left-right determination factor 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LYZ lysozyme
MINK1 misshapen-like kinase 1
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFC platelet derived growth factor C
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
RNASET2 ribonuclease T2
S100P S100 calcium binding protein P
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VWF von Willebrand factor
WSB1 WD repeat and SOCS box containing 1
ZHX2 zinc fingers and homeoboxes 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACOT9 acyl-CoA thioesterase 9
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DNM1L dynamin 1-like
DUSP2 dual specificity phosphatase 2
EGR3 early growth response 3
FAM35A family with sequence similarity 35, member A
FAR2 fatty acyl CoA reductase 2
FASTKD1 FAST kinase domains 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GPR183 G protein-coupled receptor 183
HIGD1A HIG1 hypoxia inducible domain family, member 1A
IGHM immunoglobulin heavy constant mu
KLK5 kallikrein-related peptidase 5
LDLR low density lipoprotein receptor
LMNA lamin A/C
LPL lipoprotein lipase
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MOK MOK protein kinase
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
PDE4DIP phosphodiesterase 4D interacting protein
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUF60 poly-U binding splicing factor 60KDa
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SPON1 spondin 1, extracellular matrix protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18