BRD-K43002773_GDC-0068_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K43002773_GDC-0068_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ATP9A ATPase, class II, type 9A
BACE2 beta-site APP-cleaving enzyme 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
CTSA cathepsin A
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134B family with sequence similarity 134, member B
GDF15 growth differentiation factor 15
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPNMB glycoprotein (transmembrane) nmb
HOPX HOP homeobox
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JUP junction plakoglobin
KLK11 kallikrein-related peptidase 11
KRT18 keratin 18, type I
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP2 microfibrillar-associated protein 2
MGLL monoglyceride lipase
MT1E metallothionein 1E
MTCL1 microtubule crosslinking factor 1
MTUS1 microtubule associated tumor suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
PERP PERP, TP53 apoptosis effector
PODXL podocalyxin-like
PRSS23 protease, serine, 23
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SSFA2 sperm specific antigen 2
TACC2 transforming, acidic coiled-coil containing protein 2
TANK TRAF family member-associated NFKB activator
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TUBA1A tubulin, alpha 1a
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
CRABP1 cellular retinoic acid binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
EIF5 eukaryotic translation initiation factor 5
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBD hemoglobin, delta
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA9 heat shock 70kDa protein 9 (mortalin)
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MRPL19 mitochondrial ribosomal protein L19
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAT plasminogen activator, tissue
RAD23B RAD23 homolog B (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLPI secretory leukocyte peptidase inhibitor
TCF4 transcription factor 4
VCAM1 vascular cell adhesion molecule 1