BRD-K42918627_GSK-2126458_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K42918627_GSK-2126458_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOQ adiponectin, C1Q and collagen domain containing
AREG amphiregulin
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
BZW2 basic leucine zipper and W2 domains 2
C3ORF14 chromosome 3 open reading frame 14
CA1 carbonic anhydrase I
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPU centromere protein U
CLDN4 claudin 4
CRABP2 cellular retinoic acid binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EMP1 epithelial membrane protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IER5 immediate early response 5
KIAA0101 KIAA0101
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MXI1 MAX interactor 1, dimerization protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OSER1 oxidative stress responsive serine-rich 1
PDGFRL platelet-derived growth factor receptor-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLIN1 perilipin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
STK17A serine/threonine kinase 17a
SYBU syntabulin (syntaxin-interacting)
TES testin LIM domain protein
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOM1L1 target of myb1 (chicken)-like 1
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AEBP1 AE binding protein 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
APP amyloid beta (A4) precursor protein
BCHE butyrylcholinesterase
BHLHE41 basic helix-loop-helix family, member e41
CCND1 cyclin D1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CLDN10 claudin 10
COG2 component of oligomeric golgi complex 2
CRISP3 cysteine-rich secretory protein 3
CTPS1 CTP synthase 1
CTTN cortactin
DHCR7 7-dehydrocholesterol reductase
DUOX2 dual oxidase 2
FASTKD5 FAST kinase domains 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTP1 glutathione S-transferase pi 1
HSPA1A heat shock 70kDa protein 1A
IGHM immunoglobulin heavy constant mu
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
INSIG1 insulin induced gene 1
JAG1 jagged 1
LCN2 lipocalin 2
LTF lactotransferrin
NDP Norrie disease (pseudoglioma)
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRP1B ribosomal RNA processing 1B
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
TCF4 transcription factor 4
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan