BRD-K42918627_GSK-2126458_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-K42918627_GSK-2126458_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AIM1 absent in melanoma 1
ANXA1 annexin A1
ANXA3 annexin A3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BACE2 beta-site APP-cleaving enzyme 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN10 claudin 10
CST1 cystatin SN
CTSL cathepsin L
CTSS cathepsin S
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DARS aspartyl-tRNA synthetase
DENND1B DENN/MADD domain containing 1B
DUSP4 dual specificity phosphatase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF3D eukaryotic translation initiation factor 3, subunit D
ERO1L ERO1-like (S. cerevisiae)
FOXD1 forkhead box D1
FOXO3 forkhead box O3
FZD5 frizzled class receptor 5
GDF15 growth differentiation factor 15
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLRX glutaredoxin (thioltransferase)
GPR137B G protein-coupled receptor 137B
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IL32 interleukin 32
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0430 KIAA0430
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGLL monoglyceride lipase
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NCK2 NCK adaptor protein 2
NMI N-myc (and STAT) interactor
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUCB2 nucleobindin 2
OPTN optineurin
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLIN2 perilipin 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB3 Rho-related BTB domain containing 3
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SP140L SP140 nuclear body protein-like
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC1 stanniocalcin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNIP1 TNFAIP3 interacting protein 1
TOM1L1 target of myb1 (chicken)-like 1
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TSPAN1 tetraspanin 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT1 acetyl-CoA acetyltransferase 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CYCS cytochrome c, somatic
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFS embryonal Fyn-associated substrate
EIF5A eukaryotic translation initiation factor 5A
FASN fatty acid synthase
FBLN1 fibulin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
FH fumarate hydratase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IRF4 interferon regulatory factor 4
ITGB1BP1 integrin beta 1 binding protein 1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LIMCH1 LIM and calponin homology domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MLEC malectin
MPZL1 myelin protein zero-like 1
MTA1 metastasis associated 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NPTX2 neuronal pentraxin II
NUSAP1 nucleolar and spindle associated protein 1
NVL nuclear VCP-like
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDE10A phosphodiesterase 10A
PGRMC1 progesterone receptor membrane component 1
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
PLN phospholamban
PNP purine nucleoside phosphorylase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRMT1 protein arginine methyltransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RFC4 replication factor C (activator 1) 4, 37kDa
RGS13 regulator of G-protein signaling 13
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SLBP stem-loop binding protein
SMC4 structural maintenance of chromosomes 4
SORBS1 sorbin and SH3 domain containing 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
ST7 suppression of tumorigenicity 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WDR61 WD repeat domain 61
ZWINT ZW10 interacting kinetochore protein