BRD-K42918627_GSK-2126458_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

313 genes differentially expressed following the BRD-K42918627_GSK-2126458_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD6 abhydrolase domain containing 6
ADAM28 ADAM metallopeptidase domain 28
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
AMIGO2 adhesion molecule with Ig-like domain 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN4 claudin 4
CLIC5 chloride intracellular channel 5
CRIP1 cysteine-rich protein 1 (intestinal)
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSA cathepsin A
CTSF cathepsin F
DDR1 discoidin domain receptor tyrosine kinase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DOCK9 dedicator of cytokinesis 9
DSG2 desmoglein 2
DSP desmoplakin
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
EDN3 endothelin 3
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAXDC2 fatty acid hydroxylase domain containing 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD3 FXYD domain containing ion transport regulator 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMA3 laminin, alpha 3
LAMB2 laminin, beta 2 (laminin S)
LEPROT leptin receptor overlapping transcript
LIMA1 LIM domain and actin binding 1
LRP10 low density lipoprotein receptor-related protein 10
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MECOM MDS1 and EVI1 complex locus
MGLL monoglyceride lipase
MGP matrix Gla protein
MTMR11 myotubularin related protein 11
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NUDCD3 NudC domain containing 3
OLFML2A olfactomedin-like 2A
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM5 PDZ and LIM domain 5
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2A phosphatidic acid phosphatase type 2A
PRSS2 protease, serine, 2 (trypsin 2)
PRSS23 protease, serine, 23
PRSS8 protease, serine, 8
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPL31 ribosomal protein L31
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAB1 stabilin 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM59 transmembrane protein 59
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AFP alpha-fetoprotein
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK4 adenylate kinase 4
ALB albumin
APOA2 apolipoprotein A-II
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
C1QBP complement component 1, q subcomponent binding protein
C3ORF14 chromosome 3 open reading frame 14
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKAP4 cytoskeleton-associated protein 4
CKS1B CDC28 protein kinase regulatory subunit 1B
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCTPP1 dCTP pyrophosphatase 1
DDIT4 DNA-damage-inducible transcript 4
DNA2 DNA replication helicase/nuclease 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EXOSC2 exosome component 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCLM glutamate-cysteine ligase, modifier subunit
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
IL13RA2 interleukin 13 receptor, alpha 2
ILF2 interleukin enhancer binding factor 2
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF23 kinesin family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MINA MYC induced nuclear antigen
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH2 mutS homolog 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC3IP PSMC3 interacting protein
QDPR quinoid dihydropteridine reductase
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SCARB1 scavenger receptor class B, member 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein