BRD-K42918627_GSK-2126458_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K42918627_GSK-2126458_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABI1 abl-interactor 1
ACAA2 acetyl-CoA acyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
CCNG2 cyclin G2
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRABP2 cellular retinoic acid binding protein 2
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
GDF15 growth differentiation factor 15
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
MAN1A1 mannosidase, alpha, class 1A, member 1
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGRMC2 progesterone receptor membrane component 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB27A RAB27A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RGS1 regulator of G-protein signaling 1
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
ST7 suppression of tumorigenicity 7
SYBU syntabulin (syntaxin-interacting)
TERT telomerase reverse transcriptase
TGFBI transforming growth factor, beta-induced, 68kDa
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AEBP1 AE binding protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
BAG2 BCL2-associated athanogene 2
C1R complement component 1, r subcomponent
CCND1 cyclin D1
CDC25A cell division cycle 25A
CHI3L2 chitinase 3-like 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBLN5 fibulin 5
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HES1 hes family bHLH transcription factor 1
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
KRT14 keratin 14, type I
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
NAV3 neuron navigator 3
NEBL nebulette
NKX3-1 NK3 homeobox 1
NOSIP nitric oxide synthase interacting protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDPN podoplanin
PDZK1IP1 PDZK1 interacting protein 1
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIB2 tribbles pseudokinase 2