BRD-K42918627_GSK-2126458_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K42918627_GSK-2126458_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
ITM2A integral membrane protein 2A
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LITAF lipopolysaccharide-induced TNF factor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METTL7A methyltransferase like 7A
MKNK2 MAP kinase interacting serine/threonine kinase 2
NCK1 NCK adaptor protein 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NPC2 Niemann-Pick disease, type C2
NPR3 natriuretic peptide receptor 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
OSBPL1A oxysterol binding protein-like 1A
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PAX8 paired box 8
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF13 ring finger protein 13
RPS4Y1 ribosomal protein S4, Y-linked 1
SDCBP syndecan binding protein (syntenin)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SKAP2 src kinase associated phosphoprotein 2
SLC35F2 solute carrier family 35, member F2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX7 syntaxin 7
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TAGLN2 transgelin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TSPO translocator protein (18kDa)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADCY9 adenylate cyclase 9
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BYSL bystin-like
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
JMJD6 jumonji domain containing 6
KLK10 kallikrein-related peptidase 10
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
OLFM4 olfactomedin 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRPF4 pre-mRNA processing factor 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM4 tropomyosin 4
TRIB2 tribbles pseudokinase 2
WNT5A wingless-type MMTV integration site family, member 5A