BRD-K42918627_GSK-2126458_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K42918627_GSK-2126458_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
APOD apolipoprotein D
ATF3 activating transcription factor 3
CCK cholecystokinin
CCNG2 cyclin G2
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTTN cortactin
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
EPAS1 endothelial PAS domain protein 1
FAM49A family with sequence similarity 49, member A
FGFR1 fibroblast growth factor receptor 1
GBP2 guanylate binding protein 2, interferon-inducible
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KLHL21 kelch-like family member 21
NPTXR neuronal pentraxin receptor
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE8A phosphodiesterase 8A
PEG3 paternally expressed 3
PLSCR1 phospholipid scramblase 1
PLXNB2 plexin B2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
STX1A syntaxin 1A (brain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TM4SF1 transmembrane 4 L six family member 1
WASF3 WAS protein family, member 3
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOLD1 apolipoprotein L domain containing 1
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP6 fatty acid binding protein 6, ileal
FBN2 fibrillin 2
G6PD glucose-6-phosphate dehydrogenase
GLIPR1 GLI pathogenesis-related 1
GSTA1 glutathione S-transferase alpha 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HSPA1A heat shock 70kDa protein 1A
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
LDHB lactate dehydrogenase B
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAT2A methionine adenosyltransferase II, alpha
MSMO1 methylsterol monooxygenase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NT5DC2 5'-nucleotidase domain containing 2
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PRAME preferentially expressed antigen in melanoma
RCAN1 regulator of calcineurin 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPP1 secreted phosphoprotein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28