BRD-K42918627_GSK-2126458_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K42918627_GSK-2126458_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACP5 acid phosphatase 5, tartrate resistant
ADAM28 ADAM metallopeptidase domain 28
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD36B ankyrin repeat domain 36B
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CD9 CD9 molecule
CFD complement factor D (adipsin)
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4B eukaryotic translation initiation factor 4B
FAXDC2 fatty acid hydroxylase domain containing 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GCC2 GRIP and coiled-coil domain containing 2
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
KDM5D lysine (K)-specific demethylase 5D
KLHL21 kelch-like family member 21
KYNU kynureninase
LBH limb bud and heart development
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
MCOLN1 mucolipin 1
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
PAEP progestagen-associated endometrial protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
SDCBP syndecan binding protein (syntenin)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SLC35F2 solute carrier family 35, member F2
SLC44A4 solute carrier family 44, member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
TSC22D3 TSC22 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANXA3 annexin A3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CNN3 calponin 3, acidic
CRABP2 cellular retinoic acid binding protein 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELOVL6 ELOVL fatty acid elongase 6
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IARS isoleucyl-tRNA synthetase
IGL immunoglobulin lambda locus
ILF2 interleukin enhancer binding factor 2
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
LAP3 leucine aminopeptidase 3
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NEBL nebulette
NME1 NME/NM23 nucleoside diphosphate kinase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAM peptidylglycine alpha-amidating monooxygenase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
RANBP1 RAN binding protein 1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SOX9 SRY (sex determining region Y)-box 9
SRM spermidine synthase
STIP1 stress-induced phosphoprotein 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
XIST X inactive specific transcript (non-protein coding)
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein