BRD-K42918627_GSK-2126458_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-K42918627_GSK-2126458_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACOX2 acyl-CoA oxidase 2, branched chain
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHSG alpha-2-HS-glycoprotein
AKR1C1 aldo-keto reductase family 1, member C1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANG angiogenin, ribonuclease, RNase A family, 5
APOA2 apolipoprotein A-II
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOE apolipoprotein E
APOM apolipoprotein M
ATP10A ATPase, class V, type 10A
BAG6 BCL2-associated athanogene 6
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
C5 complement component 5
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFB complement factor B
CIDEB cell death-inducing DFFA-like effector b
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
DST dystonin
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF4B eukaryotic translation initiation factor 4B
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FGG fibrinogen gamma chain
FMO5 flavin containing monooxygenase 5
FOLR1 folate receptor 1 (adult)
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GAS6 growth arrest-specific 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GRN granulin
GSDMB gasdermin B
HDAC6 histone deacetylase 6
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HP haptoglobin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP1 insulin-like growth factor binding protein 1
IRS2 insulin receptor substrate 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00341 long intergenic non-protein coding RNA 341
LONP2 lon peptidase 2, peroxisomal
LTBP3 latent transforming growth factor beta binding protein 3
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PABPC3 poly(A) binding protein, cytoplasmic 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHYH phytanoyl-CoA 2-hydroxylase
PLAC8 placenta-specific 8
PNRC1 proline-rich nuclear receptor coactivator 1
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
PYGL phosphorylase, glycogen, liver
R3HDM2 R3H domain containing 2
RAB17 RAB17, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
RELN reelin
RGN regucalcin
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC22A18 solute carrier family 22, member 18
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35E2B solute carrier family 35, member E2B
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPTBN1 spectrin, beta, non-erythrocytic 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM7SF2 transmembrane 7 superfamily member 2
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
TSC2 tuberous sclerosis 2
TSPAN31 tetraspanin 31
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VTN vitronectin
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ATAD2 ATPase family, AAA domain containing 2
ATF3 activating transcription factor 3
AURKA aurora kinase A
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CETN2 centrin, EF-hand protein, 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
DBF4 DBF4 zinc finger
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DPT dermatopontin
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLT1 dynein, light chain, Tctex-type 1
E2F8 E2F transcription factor 8
EAF2 ELL associated factor 2
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LRRC17 leucine rich repeat containing 17
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
PAK1IP1 PAK1 interacting protein 1
PALLD palladin, cytoskeletal associated protein
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHTF2 putative homeodomain transcription factor 2
PLK4 polo-like kinase 4
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TAGLN transgelin
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UFD1L ubiquitin fusion degradation 1 like (yeast)
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein