BRD-K42918627_GSK-2126458_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K42918627_GSK-2126458_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BCL2A1 BCL2-related protein A1
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
C10ORF10 chromosome 10 open reading frame 10
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CHN1 chimerin 1
CHN2 chimerin 2
COL11A1 collagen, type XI, alpha 1
CPD carboxypeptidase D
CTGF connective tissue growth factor
CTSB cathepsin B
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FAM134C family with sequence similarity 134, member C
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H2AC histone cluster 1, H2ac
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI16 interferon, gamma-inducible protein 16
INSR insulin receptor
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM3A lysine (K)-specific demethylase 3A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METTL7A methyltransferase like 7A
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
MYO6 myosin VI
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NSG1 neuron specific gene family member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PTN pleiotrophin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1CC1 RB1-inducible coiled-coil 1
RELN reelin
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC35E2B solute carrier family 35, member E2B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SSPN sarcospan
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
THEMIS2 thymocyte selection associated family member 2
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UBE2B ubiquitin-conjugating enzyme E2B
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA3 annexin A3
ATG3 autophagy related 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AXL AXL receptor tyrosine kinase
BIN1 bridging integrator 1
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAV2 caveolin 2
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
DLC1 DLC1 Rho GTPase activating protein
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
H2AFX H2A histone family, member X
HHEX hematopoietically expressed homeobox
HN1 hematological and neurological expressed 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC59 leucine rich repeat containing 59
MCM2 minichromosome maintenance complex component 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYOF myoferlin
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPR3 natriuretic peptide receptor 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PRDX2 peroxiredoxin 2
PTRF polymerase I and transcript release factor
RANBP1 RAN binding protein 1
S100A2 S100 calcium binding protein A2
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SRM spermidine synthase
STAT1 signal transducer and activator of transcription 1, 91kDa
STRA13 stimulated by retinoic acid 13
TPM1 tropomyosin 1 (alpha)
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon