BRD-K42918627_GSK-2126458_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

321 genes differentially expressed following the BRD-K42918627_GSK-2126458_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP9A ATPase, class II, type 9A
BCL2L2 BCL2-like 2
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CANX calnexin
CAPN3 calpain 3, (p94)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK12 cyclin-dependent kinase 12
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
COL9A2 collagen, type IX, alpha 2
COMP cartilage oligomeric matrix protein
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPQ carboxypeptidase Q
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
DDIT3 DNA-damage-inducible transcript 3
DIAPH2 diaphanous-related formin 2
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP4 dipeptidyl-peptidase 4
DUSP4 dual specificity phosphatase 4
DYNLT3 dynein, light chain, Tctex-type 3
EFNA1 ephrin-A1
EPN2 epsin 2
ETV1 ets variant 1
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAB2 GRB2-associated binding protein 2
GATAD1 GATA zinc finger domain containing 1
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HDAC9 histone deacetylase 9
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2R insulin-like growth factor 2 receptor
IL1B interleukin 1, beta
IPO13 importin 13
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA1033 KIAA1033
KLF5 Kruppel-like factor 5 (intestinal)
KLHL21 kelch-like family member 21
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LOC100272216 uncharacterized LOC100272216
LOC399491
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIT1 nitrilase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OFD1 oral-facial-digital syndrome 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PARP6 poly (ADP-ribose) polymerase family, member 6
PARVA parvin, alpha
PDE4DIP phosphodiesterase 4D interacting protein
PDZRN3 PDZ domain containing ring finger 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLXNA1 plexin A1
PMP22 peripheral myelin protein 22
POPDC3 popeye domain containing 3
PRKD1 protein kinase D1
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RAB29 RAB29, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAGC Ras-related GTP binding C
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SDCBP syndecan binding protein (syntenin)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18 solute carrier family 22, member 18
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC35E2B solute carrier family 35, member E2B
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAP1 small ArfGAP 1
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VPS13B vacuolar protein sorting 13 homolog B (yeast)
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CLU clusterin
CNN3 calponin 3, acidic
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYB5A cytochrome b5 type A (microsomal)
DBF4 DBF4 zinc finger
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EIF4E eukaryotic translation initiation factor 4E
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GMNN geminin, DNA replication inhibitor
HAT1 histone acetyltransferase 1
HDAC2 histone deacetylase 2
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HLTF helicase-like transcription factor
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HN1 hematological and neurological expressed 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT5 keratin 5, type II
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
NXT1 nuclear transport factor 2-like export factor 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PBX2 pre-B-cell leukemia homeobox 2
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PLAC8 placenta-specific 8
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPARG peroxisome proliferator-activated receptor gamma
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCB protein kinase C, beta
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RBBP8 retinoblastoma binding protein 8
RBP1 retinol binding protein 1, cellular
RBX1 ring-box 1, E3 ubiquitin protein ligase
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SELT selenoprotein T
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPG small nuclear ribonucleoprotein polypeptide G
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1
YME1L1 YME1-like 1 ATPase
ZFP36L1 ZFP36 ring finger protein-like 1
ZWINT ZW10 interacting kinetochore protein