BRD-K42805893_HG-14-8-02_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K42805893_HG-14-8-02_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARL4C ADP-ribosylation factor-like 4C
C14ORF132 chromosome 14 open reading frame 132
C1S complement component 1, s subcomponent
C3 complement component 3
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC92 coiled-coil domain containing 92
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CLIC5 chloride intracellular channel 5
CP ceruloplasmin (ferroxidase)
CTSA cathepsin A
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFB1 defensin, beta 1
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP3 dual specificity phosphatase 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FXYD2 FXYD domain containing ion transport regulator 2
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
GUSBP3 glucuronidase, beta pseudogene 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HP haptoglobin
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL6R interleukin 6 receptor
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LRRC16A leucine rich repeat containing 16A
LY75 lymphocyte antigen 75
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MN1 meningioma (disrupted in balanced translocation) 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEU1 sialidase 1 (lysosomal sialidase)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1IP1 PDZK1 interacting protein 1
PLA2G16 phospholipase A2, group XVI
PNMA2 paraneoplastic Ma antigen 2
PRSS23 protease, serine, 23
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM47 RNA binding motif protein 47
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RNF11 ring finger protein 11
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TM7SF2 transmembrane 7 superfamily member 2
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
TXNL4B thioredoxin-like 4B
UGDH UDP-glucose 6-dehydrogenase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BDNF brain-derived neurotrophic factor
CCNA2 cyclin A2
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL1A2 collagen, type I, alpha 2
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYTL1 cytokine-like 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
FST follistatin
FXYD6 FXYD domain containing ion transport regulator 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HBEGF heparin-binding EGF-like growth factor
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IL13RA2 interleukin 13 receptor, alpha 2
KIF14 kinesin family member 14
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LMO4 LIM domain only 4
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MINA MYC induced nuclear antigen
MKNK2 MAP kinase interacting serine/threonine kinase 2
MRPL19 mitochondrial ribosomal protein L19
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NBL1 neuroblastoma 1, DAN family BMP antagonist
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM1 PDZ and LIM domain 1
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRNP prion protein
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
TBX3 T-box 3
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UCHL5 ubiquitin carboxyl-terminal hydrolase L5