BRD-K42436189_AZ20_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K42436189_AZ20_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
AIM1 absent in melanoma 1
AIM2 absent in melanoma 2
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AREG amphiregulin
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL8 chemokine (C-C motif) ligand 8
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CIRBP cold inducible RNA binding protein
CKM creatine kinase, muscle
CLCA2 chloride channel accessory 2
CLDN4 claudin 4
CTSH cathepsin H
CTSL cathepsin L
CXCL9 chemokine (C-X-C motif) ligand 9
DCLK1 doublecortin-like kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DSC2 desmocollin 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM3C family with sequence similarity 3, member C
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2AC histone cluster 1, H2ac
IER5 immediate early response 5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB5 integrin, beta 5
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
LETMD1 LETM1 domain containing 1
LRP10 low density lipoprotein receptor-related protein 10
MBNL2 muscleblind-like splicing regulator 2
MEF2C myocyte enhancer factor 2C
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYO6 myosin VI
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NOVA1 neuro-oncological ventral antigen 1
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OSR2 odd-skipped related transciption factor 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK2 polo-like kinase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
PSAP prosaposin
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL22 ribosomal protein L22
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEAL4 transcription elongation factor A (SII)-like 4
TNNI2 troponin I type 2 (skeletal, fast)
TPD52L1 tumor protein D52-like 1
TRAPPC6A trafficking protein particle complex 6A
TRIM22 tripartite motif containing 22
TRIP6 thyroid hormone receptor interactor 6
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase
VDAC1 voltage-dependent anion channel 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
BPHL biphenyl hydrolase-like (serine hydrolase)
C3 complement component 3
CA2 carbonic anhydrase II
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBR1 carbonyl reductase 1
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CD58 CD58 molecule
CDC6 cell division cycle 6
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL9A3 collagen, type IX, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CXCL5 chemokine (C-X-C motif) ligand 5
DSCC1 DNA replication and sister chromatid cohesion 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FN1 fibronectin 1
FOXF1 forkhead box F1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
GTF2A2 general transcription factor IIA, 2, 12kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IQGAP2 IQ motif containing GTPase activating protein 2
ITM2A integral membrane protein 2A
KLHL7 kelch-like family member 7
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MCM6 minichromosome maintenance complex component 6
NAE1 NEDD8 activating enzyme E1 subunit 1
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDE8A phosphodiesterase 8A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM1 PDZ and LIM domain 1
PDZD2 PDZ domain containing 2
PHGDH phosphoglycerate dehydrogenase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
RAD51C RAD51 paralog C
RASIP1 Ras interacting protein 1
RGCC regulator of cell cycle
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOD2 superoxide dismutase 2, mitochondrial
SOSTDC1 sclerostin domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TAGLN2 transgelin 2
TCTN1 tectonic family member 1
TF transferrin
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TMEM126B transmembrane protein 126B
TMEM204 transmembrane protein 204
TPPP3 tubulin polymerization-promoting protein family member 3
TREM1 triggering receptor expressed on myeloid cells 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)