BRD-K42436189_AZ20_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K42436189_AZ20_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADGRE5 adhesion G protein-coupled receptor E5
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGAP5 Rho GTPase activating protein 5
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DGKA diacylglycerol kinase, alpha 80kDa
DPP4 dipeptidyl-peptidase 4
DUSP10 dual specificity phosphatase 10
EAPP E2F-associated phosphoprotein
EGR1 early growth response 1
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLS glutaminase
GREM1 gremlin 1, DAN family BMP antagonist
GSE1 Gse1 coiled-coil protein
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
IGF1R insulin-like growth factor 1 receptor
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM5B lysine (K)-specific demethylase 5B
LAMB3 laminin, beta 3
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOAP1 modulator of apoptosis 1
MVP major vault protein
NGRN neugrin, neurite outgrowth associated
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RAP1GAP2 RAP1 GTPase activating protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS27L ribosomal protein S27-like
RRAGD Ras-related GTP binding D
SCAND1 SCAN domain containing 1
SESN1 sestrin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOCS2 suppressor of cytokine signaling 2
SRP54 signal recognition particle 54kDa
STAT1 signal transducer and activator of transcription 1, 91kDa
STK26 serine/threonine protein kinase 26
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM7SF2 transmembrane 7 superfamily member 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM22 tripartite motif containing 22
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANXA2 annexin A2
ATAD2 ATPase family, AAA domain containing 2
BAD BCL2-associated agonist of cell death
BIRC5 baculoviral IAP repeat containing 5
C20ORF27 chromosome 20 open reading frame 27
CA12 carbonic anhydrase XII
CALR calreticulin
CCNA2 cyclin A2
CCNF cyclin F
CDC42 cell division cycle 42
COL3A1 collagen, type III, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CXCL6 chemokine (C-X-C motif) ligand 6
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DNM1 dynamin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FEN1 flap structure-specific endonuclease 1
FGFR1 fibroblast growth factor receptor 1
FRZB frizzled-related protein
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRWD1 glutamate-rich WD repeat containing 1
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LMNB1 lamin B1
LTF lactotransferrin
MATN2 matrilin 2
MEX3D mex-3 RNA binding family member D
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OIP5 Opa interacting protein 5
PBX1 pre-B-cell leukemia homeobox 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPID peptidylprolyl isomerase D
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP1 retinol binding protein 1, cellular
RGL1 ral guanine nucleotide dissociation stimulator-like 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
TACC1 transforming, acidic coiled-coil containing protein 1
TCTN1 tectonic family member 1
TFDP1 transcription factor Dp-1
TNPO1 transportin 1
TUBB2A tubulin, beta 2A class IIa
ZIC1 Zic family member 1