BRD-K42191735_buparlisib_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K42191735_buparlisib_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
AIM1 absent in melanoma 1
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
BDKRB2 bradykinin receptor B2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CFD complement factor D (adipsin)
CLIC5 chloride intracellular channel 5
COCH cochlin
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP22 dual specificity phosphatase 22
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER3 homer scaffolding protein 3
HSPB8 heat shock 22kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
KDM5B lysine (K)-specific demethylase 5B
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
NT5E 5'-nucleotidase, ecto (CD73)
ORAI3 ORAI calcium release-activated calcium modulator 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLVAP plasmalemma vesicle associated protein
PRKX protein kinase, X-linked
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
VCAN versican
VEGFC vascular endothelial growth factor C
WDR45 WD repeat domain 45
WNK1 WNK lysine deficient protein kinase 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CHERP calcium homeostasis endoplasmic reticulum protein
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EFHD2 EF-hand domain family, member D2
ELAVL1 ELAV like RNA binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
GAS1 growth arrest-specific 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HOXC6 homeobox C6
IFRD2 interferon-related developmental regulator 2
IL1RN interleukin 1 receptor antagonist
IPO5 importin 5
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LBR lamin B receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAMLD1 mastermind-like domain containing 1
MCAM melanoma cell adhesion molecule
MCM4 minichromosome maintenance complex component 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
PA2G4 proliferation-associated 2G4, 38kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPATS2L spermatogenesis associated, serine-rich 2-like
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM97 transmembrane protein 97
TMPO thymopoietin
TUBB tubulin, beta class I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)