BRD-K42191735_buparlisib_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

131 genes differentially expressed following the BRD-K42191735_buparlisib_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
AKAP13 A kinase (PRKA) anchor protein 13
APOE apolipoprotein E
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
CCDC28A coiled-coil domain containing 28A
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST1 cystatin SN
CXCL8 chemokine (C-X-C motif) ligand 8
CYTH1 cytohesin 1
DST dystonin
EGFR epidermal growth factor receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JUP junction plakoglobin
KIF13B kinesin family member 13B
KIF14 kinesin family member 14
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL7A methyltransferase like 7A
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NTS neurotensin
OSBPL8 oxysterol binding protein-like 8
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB31 RAB31, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDCBP syndecan binding protein (syntenin)
SGK1 serum/glucocorticoid regulated kinase 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SRGN serglycin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM50A transmembrane protein 50A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AK2 adenylate kinase 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ANOS1 anosmin 1
ASPH aspartate beta-hydroxylase
BAD BCL2-associated agonist of cell death
BZW2 basic leucine zipper and W2 domains 2
C8ORF33 chromosome 8 open reading frame 33
CA2 carbonic anhydrase II
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDK4 cyclin-dependent kinase 4
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DCTPP1 dCTP pyrophosphatase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
LIMCH1 LIM and calponin homology domains 1
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MFAP5 microfibrillar associated protein 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PFN2 profilin 2
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RBM3 RNA binding motif (RNP1, RRM) protein 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SET SET nuclear proto-oncogene
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
STC2 stanniocalcin 2
TYMS thymidylate synthetase