BRD-K41895714_AS-605240_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K41895714_AS-605240_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOC1 apolipoprotein C-I
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
COMT catechol-O-methyltransferase
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
ENO2 enolase 2 (gamma, neuronal)
EVL Enah/Vasp-like
GLS glutaminase
GPER1 G protein-coupled estrogen receptor 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT5 keratin 5, type II
LBH limb bud and heart development
MARCKSL1 MARCKS-like 1
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSRB2 methionine sulfoxide reductase B2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PRKCD protein kinase C, delta
REEP1 receptor accessory protein 1
ROGDI rogdi homolog (Drosophila)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX11 sorting nexin 11
SPATA20 spermatogenesis associated 20
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPN asporin
CCND1 cyclin D1
CCND2 cyclin D2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL2A1 collagen, type II, alpha 1
COMP cartilage oligomeric matrix protein
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBN1 fibrillin 1
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HELLS helicase, lymphoid-specific
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
ITGB5 integrin, beta 5
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
NOLC1 nucleolar and coiled-body phosphoprotein 1
NT5E 5'-nucleotidase, ecto (CD73)
PLSCR1 phospholipid scramblase 1
PPARG peroxisome proliferator-activated receptor gamma
PRSS3 protease, serine, 3
RPL39L ribosomal protein L39-like
S100P S100 calcium binding protein P
SPP1 secreted phosphoprotein 1
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
THBS4 thrombospondin 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1