BRD-K41895714_AS-605240_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K41895714_AS-605240_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ACTC1 actin, alpha, cardiac muscle 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BASP1 brain abundant, membrane attached signal protein 1
CFB complement factor B
CXCL12 chemokine (C-X-C motif) ligand 12
DAPK1 death-associated protein kinase 1
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KRT7 keratin 7, type II
LRRN3 leucine rich repeat neuronal 3
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCDH9 protocadherin 9
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS11 ribosomal protein S11
SNAP25 synaptosomal-associated protein, 25kDa
SULF1 sulfatase 1
SYT1 synaptotagmin I
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CARD10 caspase recruitment domain family, member 10
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDCP1 CUB domain containing protein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CSNK1E casein kinase 1, epsilon
CST1 cystatin SN
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GSAP gamma-secretase activating protein
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
ITGA6 integrin, alpha 6
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LAMB3 laminin, beta 3
LIF leukemia inhibitory factor
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NT5E 5'-nucleotidase, ecto (CD73)
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
RGCC regulator of cell cycle
SDC4 syndecan 4
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SLC38A1 solute carrier family 38, member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1