BRD-K41895714_AS-605240_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K41895714_AS-605240_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOC1 apolipoprotein C-I
ARG1 arginase 1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
C5 complement component 5
CAST calpastatin
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CRYAB crystallin, alpha B
CYB5A cytochrome b5 type A (microsomal)
DEFB1 defensin, beta 1
DUSP22 dual specificity phosphatase 22
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
GLUL glutamate-ammonia ligase
GSTA4 glutathione S-transferase alpha 4
HBB hemoglobin, beta
HDAC6 histone deacetylase 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSDL2 hydroxysteroid dehydrogenase like 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LY6D lymphocyte antigen 6 complex, locus D
LYST lysosomal trafficking regulator
MAGED1 melanoma antigen family D1
MTSS1 metastasis suppressor 1
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PDLIM1 PDZ and LIM domain 1
PHYH phytanoyl-CoA 2-hydroxylase
QKI QKI, KH domain containing, RNA binding
S100A8 S100 calcium binding protein A8
SESN1 sestrin 1
SPRR1A small proline-rich protein 1A
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TP63 tumor protein p63
TSKU tsukushi, small leucine rich proteoglycan

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
C7 complement component 7
CD200 CD200 molecule
CD24 CD24 molecule
CDV3 CDV3 homolog (mouse)
CEMIP cell migration inducing protein, hyaluronan binding
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAT1 FAT atypical cadherin 1
FBXO21 F-box protein 21
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMA3 laminin, alpha 3
LAMB1 laminin, beta 1
LPAR6 lysophosphatidic acid receptor 6
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MSLN mesothelin
NID1 nidogen 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
ODC1 ornithine decarboxylase 1
OSBPL10 oxysterol binding protein-like 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
RND3 Rho family GTPase 3
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35G2 solute carrier family 35, member G2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
TACSTD2 tumor-associated calcium signal transducer 2
TFDP1 transcription factor Dp-1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TSPAN4 tetraspanin 4
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF423 zinc finger protein 423